Protein Family Models

This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [1]. This family also includes tafazzin Swiss:Q16635, the Barth syndrome gene [2]. [1]. 9259571. Barth syndrome may be due to an acyltransferase deficiency. Neuwald AF;. Curr Biol 1997;7:465-466. [2]. 8630491. A novel X-linked gene, G4.5. is responsible for Barth syndrome. Bione S, D'Adamo P, Maestrini E, Gedeon AK, Bolhuis PA, Toniolo D;. Nat Genet 1996;12:385-389. (from Pfam)

Date:

2024-10-16

This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase.

Date:

2024-05-30