Protein Family Models

This family consists of membrane insertion efficiency factor proteins. They contain three conserved cysteine residues. Family members such as YidD may be involved in insertion of integral membrane proteins into the membrane by assisting YidC (membrane protein insertase). Some members of the yidD family have been previously thought to posses alpha-hemolysin activity, however no sufficient evidence was found to corroborate this idea. Secondary structure prediction indicated the presence of three alpha-helices in YidD. None of the three alpha-helices appeared sufficiently hydrophobic to serve as a transmembrane, suggesting a cytoplasmic localization for YidD. However, a closer examination of the alpha-helical wheel projection of the predicted first alpha-helix in YidD suggested an amphipathic structure in its N-terminal region which might be involved in membrane targeting [1]. [1]. 21803992. Role for Escherichia coli YidD in membrane protein insertion. Yu Z, Laven M, Klepsch M, de Gier JW, Bitter W, van Ulsen P, Luirink J;. J Bacteriol. 2011;193:5242-5251. (from Pfam)

Gene:

yidD

Date:

2024-10-16

This HMM describes a family, YidD, of usually small, non-essential proteins now suggested to improve YidC-dependent inner membrane protein insertion. A related protein is found in the temperature phage HP1 of Haemophilus influenzae.

Gene:

yidD

Date:

2022-03-21

membrane protein insertion efficiency factor YidD may be involved in the insertion of integral membrane proteins into the membrane

Date:

2024-12-19