Protein Family Models

SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway. Structure of SIS domain. [1]. 9739095. Involvement of the C terminus in intramolecular nitrogen channeling in glucosamine 6-phosphate synthase: evidence from a 1.6 A crystal structure of the isomerase domain. Teplyakov A, Obmolova G, Badet-Denisot MA, Badet B, Polikarpov I;. Structure 1998;6:1047-1055. [2]. 10203754. The SIS domain: a phosphosugar-binding domain. Bateman A;. Trends Biochem Sci 1999;24:94-95. (from Pfam)

Date:

2024-10-16

This domain contains a helix-turn-helix motif [1]. The best characterised member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene. [1]. 8576032. Ribose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression. Sorensen KI, Hove-Jensen B;. J Bacteriol 1996;178:1003-1011. (from Pfam)

Date:

2024-10-16

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

Date:

2024-04-18