Protein Family Models

Fumarate reductase is a membrane-bound flavoenzyme consisting of four subunits, A-B. A and B comprise the membrane-extrinsic catalytic domain and C and D link the catalytic centres to the electron-transport chain. This family consists of the 15kD hydrophobic subunit C. [1]. 3308458. Nucleotide sequence and comparative analysis of the frd operon encoding the fumarate reductase of Proteus vulgaris. Extensive sequence divergence of the membrane anchors and absence of an frd-linked ampC cephalosporinase gene. Cole ST;. Eur J Biochem 1987;167:481-488. (from Pfam)

Date:

2024-10-16

Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB

Gene:

frdC

Date:

2023-01-04

quinol:fumarate reductase transmembrane subunit C, together with the D subunit, acts to anchor the catalytic components of fumarate reductase to the cytoplasmic membrane

Date:

2016-05-13