Protein Family Models

This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00589. (from Pfam)

Date:

2024-08-14

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda. integrase catalytic core.. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131.. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a. site-specific recombination synapse.. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

Date:

2024-08-14

Tn4401 is a Tn3-related plasmid-borne transposon that contains IS (insertion sequence) elements ISKpn6 and ISKpn7, and a clinically important antibiotic resistance determinant, the carbapenem-hydrolyzing class A beta-lactamase KPC-2.

Gene:

tnpR

Date:

2022-10-11

DUF3701 domain-containing tyrosine based site-specific recombinase (integrase) is involved in cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct

Date:

2020-08-17