Protein Family Models

This family is part of the major facilitator superfamily of membrane transport proteins. (from Pfam)

Date:

2024-08-14

Gene:

melB

Date:

2022-10-11

melibiose:sodium symporter is responsible for the transport of melibiose and other galactosides using coupling cations such as hydrogen, sodium, and lithium for cotransport, depending on the particular sugar transported (symport system)

Date:

2016-05-20

The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners.

Date:

2022-10-11