Protein Family Models

This entry represents the SMEK domain, which is found at the N-terminal end of a group of bacterial proteins. It is named after four genera in which multiple, diverse members of this group of bacterial proteins are found: Staphylococcus, Mycoplasma, Escherichia, and Klebsiella. The SMEK domain is predicted to adopt an alpha/beta fold that resembles the core of restriction endonuclease enzymes. It contains four scattered invariant residues (Glu, Asp, Gln, and Lys) that may be functionally relevant. (from Pfam)

Date:

2024-10-16

The SMEK domain is named for four genera in which multiple, diverse members of this uncommon family of bacterial proteins are found: Staphylococcus, Mycoplasma, Escherichia, and Klebsiella. Members of the family are highly variable in length. This domain occurs as the N-terminal region. The four scattered invariant residues in the seed alignment, which may provide a clue to function, are Glu, Asp, Gln, and Lys.

Date:

2022-03-28