Protein Family Models

These repeats are found in many mycobacterial proteins. These repeats are most common in the Pfam:PF00823 family of proteins, where they are found in the MPTR subfamily of PPE proteins. The function of these repeats is unknown. The repeat can be approximately described as XNXGX, where X can be any amino acid. These repeats are similar to Pfam:PF00805 [1], however it is not clear if these two families are structurally related. [1]. 9655353. Structure and distribution of pentapeptide repeats in bacteria. Bateman A, Murzin A, Teichmann SA;. Protein Sci 1998;7:1477-1480. [2]. 9634230. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jage. Nature 1998;393:537-544. (from Pfam)

Date:

2024-10-16

This family named after a PPE motif near to the amino terminus of the domain. The PPE family of proteins all contain an amino-terminal region of about 180 amino acids. The carboxyl terminus of this family are variable, and on the basis of this region fall into at least three groups. The MPTR subgroup has tandem copies of a motif NXGXGNXG. The second subgroup contains a conserved motif at about position 350. The third group are only related in the amino terminal region. The function of these proteins is uncertain but it has been suggested that they may be related to antigenic variation of Mycobacterium tuberculosis [1]. [1]. 9634230. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jage. Nature 1998;393:537-544. [2]. 16690741. Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, Eisenberg D;. Proc Natl Acad Sci U S A. 2006;103:8060-8065. (from Pfam)

Date:

2024-10-16

proline-proline-glutamate (PPE) family protein similar to various Mycobacterium tuberculosis PPE virulence/immunogenicity factors

Date:

2018-12-13