Protein Family Models

MRM3 catalyses the formation of 2'-O-methylguanosine at position 1370 Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA [1-3]. This entry represents the substrate binding domain of MRM3 from animals and related sequences from bacteria. Paper describing PDB structure 1ipa. [1]. 12077432. An enzyme with a deep trefoil knot for the active-site architecture. Nureki O, Shirouzu M, Hashimoto K, Ishitani R, Terada T, Tamakoshi M, Oshima T, Chijimatsu M, Takio K, Vassylyev DG, Shibata T, Inoue Y, Kuramitsu S, Yokoyama S;. Acta Crystallogr D Biol Crystallogr. 2002;58:1129-1137. Paper describing PDB structure 1x7o. [2]. 15581897. Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. Mosbacher TG, Bechthold A, Schulz GE;. J Mol Biol. 2005;345:535-545. Paper describing PDB structure 7oi6. [3]. 34315873. A distinct assembly pathway of the human 39S late pre-mitoribosome. Cheng J, Berninghausen O, Beckmann R;. Nat Commun. 2021;12:4544. (from Pfam)

Date:

2024-10-16

This domain is a RNA 2'-O ribose methyltransferase substrate binding domain. (from Pfam)

Date:

2024-08-14

This family of proteins probably use S-AdoMet. [1]. 8265370. SpoU protein of Escherichia coli belongs to a new family of putative rRNA methylases. Koonin EV, Rudd KE;. Nucleic Acids Res 1993;21:5519-5519. [2]. 9321663. The spoU gene of escherichia coli , the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2 ' - O -methyltransferase activity. Persson BC, Jager G, Gustafsson C;. Nucleic Acids Res 1997;25:4093-4097. (from Pfam)

Date:

2024-10-16

TrmH family RNA methyltransferase catalyzes the methylation of rRNA or tRNA at specific sites in a S-adenosyl-L-methionine (SAM)-dependent manner

Date:

2024-05-01