Protein Family Models

This family is a four helix bundle that operates as a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors. This domain recognises citrate and TCA cycle intermediates, cis-aconitate, boric acid, Phenanthrene, pyrene and benzopyrene (Matilla et el., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 16306392. Four-helix bundle: a ubiquitous sensory module in prokaryotic signal transduction. Ulrich LE, Zhulin IB;. Bioinformatics. 2005;21:iii45-iii48. (from Pfam)

Date:

2024-10-16

This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors, such as E.coli Tar (taxis to aspartate and repellents), which is a receptor for the attractant L-aspartate [1,2] and also recognises proteogenic amino acids, phthalic acid, Malic acid, 3,4-dihydroxymandelic acid, citrate, benzoate and derivatives, protocatechuate, vanillate, quinate, shikimate and dehydroshikimate (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 1660187. Three-dimensional structures of the ligand-binding domain of the bacterial aspartate receptor with and without a ligand. Milburn MV, Prive GG, Milligan DL, Scott WG, Yeh J, Jancarik J, Koshland DE Jr, Kim SH;. Science. 1991;254:1342-1347. [2]. 27292793. Structural Analysis of the Ligand-Binding Domain of the Aspartate Receptor Tar from Escherichia coli. Mise T;. Biochemistry. 2016;55:3708-3713. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs. [1]. 1601874. Sequence and characterization of Bacillus subtilis CheW. Hanlon DW, Marquez-Magana LM, Carpenter PB, Chamberlin MJ, Ordal GW;. J Biol Chem 1992;267:12055-12060. (from Pfam)

Date:

2024-10-16