Protein Family Models

This region family is found at the C-terminus of the DeaD helicase, which are involved in various cellular processes such as transcription, translation and DNA recombination [1]. This region contains several repeats which contain an ERRE sequence motif. [1]. 8552679. Cold shock induces a major ribosomal-associated protein that unwinds double-stranded RNA in Escherichia coli. Jones PG, Mitta M, Kim Y, Jiang W, Inouye M;. Proc Natl Acad Sci U S A. 1996;93:76-80. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

This RNA binding domain is found at the C-terminus of a number of DEAD helicase proteins [1]. It is sufficient to confer specificity for hairpin 92 of 23S rRNA, which is part of the ribosomal A-site. However, several members of this family lack specificity for 23S rRNA. These can proteins can generally be distinguished by a basic region that extends beyond this domain [Karl Kossen, unpublished data]. [1]. 10481020. Cloning and biochemical characterization of Bacillus subtilis YxiN, a DEAD protein specifically activated by 23S rRNA: delineation of a novel sub-family of bacterial DEAD proteins. Kossen K, Uhlenbeck OC;. Nucleic Acids Res 1999;27:3811-3820. [2]. 12460566. The carboxy-terminal domain of the DExDH protein YxiN is sufficient to confer specificity for 23S rRNA. Kossen K, Karginov FV, Uhlenbeck OC;. J Mol Biol 2002;324:625-636. (from Pfam)

Date:

2024-10-16

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression. [1]. 10322435. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. de la Cruz J, Kressler D, Linder P;. Trends Biochem Sci 1999;24:192-198. [2]. 9862990. The DEAD box RNA helicase family in Arabidopsis thaliana. Aubourg S, Kreis M, Lecharny A;. Nucleic Acids Res 1999;27:628-636. (from Pfam)

Date:

2024-10-16

The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase. (from Pfam)

Date:

2024-08-14

Date:

2021-10-28

ATP-dependent RNA helicase DeaD is DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation

Date:

2019-07-29