Protein Family Models

This domain is always found with a pair of CBS domains Pfam:PF00571. (from Pfam)

Date:

2024-08-14

HrcA is found to negatively regulate the transcription of heat shock genes [1,2]. HrcA contains an amino terminal helix-turn-helix domain, however this corresponds to the carboxy terminal domain. [1]. 8576042. hrcA, the first gene of the Bacillus subtilis dnaK operon encodes a negative regulator of class I heat shock genes. Schulz A, Schumann W;. J Bacteriol 1996;178:1088-1093. [2]. 8606155. Identification of a Caulobacter crescentus operon encoding hrcA, involved in negatively regulating heat-inducible transcription, and the chaperone gene grpE. Roberts RC, Toochinda C, Avedissian M, Baldini RL, Gomes SL, Shapiro L;. J Bacteriol 1996;178:1829-1841. (from Pfam)

Date:

2024-10-16

HrcA family transcriptional regulator such as heat-inducible transcription repressor HrcA, which is a negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons)

Date:

2024-07-19

HrcA represses the class I heat shock operons groE and dnaK; overproduction prevents induction of these operons by heat shock while deletion allows constitutive expression even at low temperatures. In Bacillus subtilis, hrcA is the first gene of the dnaK operon and so is itself a heat shock gene.

Gene:

hrcA

Date:

2024-05-16