Protein Family Models

Homologs of Rv0340 from Mycobacterium tuberculosis H37Rv are regularly found encoded upstream of the genes for IniB, IniA, and IniC. As with those families, mutation in this family can contribute to resistance to isoniazid, a front-line treatment for Mycobacterium tuberculosis that works by inhibiting cell wall biosynthesis. Rv0340 and glycine-rich repetive protein IniB are homologous across the N-terminal 50 amino acids of each, but otherwise dissimilar.

Date:

2024-10-01

This domain is found as the N-terminal fifty amino acids of a number low-complexity proteins that often bear little or no similarity to each other elsewhere in the protein. The domain occurs twice in Mycobacterium tuberculosis strain H37Rv, in two adjacent proteins, Rv0340 and the isoniazid inducible protein IniB (Rv0341).

Date:

2020-10-26