Protein Family Models for Protein (Select 489336163) - Protein Family Models

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Items: 5

Select item 4176531.

pyrroloquinoline quinone precursor peptide PqqA

This family consists of proteins belonging to the coenzyme Pyrroloquinoline quinone A (pqqA) family. PQQ is the non-covalently bounded prosthetic group of many quinoproteins catalysing reactions in the periplasm of Gram-negative bacteria. PQQ is formed by the fusion of glutamate and tyrosine and synthesis of PQQ require the proteins encoded by the pqqABCDEF operon but details of the biosynthetic pathway are unclear [1]. [1]. 9889976. The biochemistry, physiology and genetics of PQQ and. PQQ-containing enzymes.. Goodwin PM, Anthony C;. Adv Microb Physiol 1998;40:1-80. (from Pfam)

Gene:: pqqA

GO Terms:

Biological Process:: pyrroloquinoline quinone biosynthetic process (GO:0018189)

Date:: 2024-08-14

Family Accession:: NF019654.5
Method:: HMM

Select item 3944442.

new record, indexing in progress

Family Accession:

Select item 3535223.

new record, indexing in progress

Family Accession:

Select item 2512874.

pyrroloquinoline quinone precursor peptide PqqA

pyrroloquinoline quinone precursor peptide PqqA is required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis

Date:: 2020-11-24

Family Accession:: 10011357
Method:: Sparcle

Select item 1435865.

pyrroloquinoline quinone precursor peptide PqqA

This HMM describes a very small protein, coenzyme PQQ biosynthesis protein A, which is smaller than 25 amino acids in many species. It is a peptide precursor of coenzyme pyrrolo-quinoline-quinone (PQQ), with Glu (E) and Tyr (Y) of a conserved motif Glu-Xxx-Xxx-Xxx-Tyr becoming part of the product. The most critical step, the cross-linking of E to Y, is catalyzed by radical SAM enzyme PqqE. Note that an analogous process occurs in mycofactocin biosynthesis, with radical SAM enzyme MftC acting on precursor peptide MftA.