Protein Family Models

This family consists of disulfide bond formation protein DsbB from bacteria. The DsbB protein oxidises the periplasmic protein DsbA which in turn oxidises cysteines in other periplasmic proteins in order to make disulfide bonds [1]. DsbB acts as a redox potential transducer across the cytoplasmic membrane and is an integral membrane protein [2]. DsbB posses six cysteines four of which are necessary for it proper function in vivo [1]. [1]. 7957076. Two cysteines in each periplasmic domain of the membrane protein DsbB are required for its function in protein disulfide bond formation. Jander G, Martin NL, Beckwith J;. EMBO J 1994;13:5121-5127. [2]. 8430071. A pathway for disulfide bond formation in vivo. Bardwell JC, Lee JO, Jander G, Martin N, Belin D, Beckwith J;. Proc Natl Acad Sci U S A 1993;90:1038-1042. (from Pfam)

Date:

2024-10-16

disulfide bond formation protein B catalyzes disulfide bond formation in some periplasmic proteins

Date:

2016-01-19