Protein Family Models

This family includes single stranded binding proteins and also the primosomal replication protein N (PriB). PriB forms a complex with PriA, PriC and ssDNA. [1]. 9192620. Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution. Raghunathan S, Ricard CS, Lohman TM, Waksman G;. Proc Natl Acad Sci U S A 1997;94:6652-6657. [2]. 9033597. Crystal structure of human mitochondrial single-stranded DNA binding protein at 2.4 A resolution. Yang C, Curth U, Urbanke C, Kang C;. Nat Struct Biol 1997;4:153-157. [3]. 9271227. A common core for binding single-stranded DNA: structural comparison of the single-stranded DNA-binding proteins (SSB) from E. coli and human mitochondria. Webster G, Genschel J, Curth U, Urbanke C, Kang C, Hilgenfeld R;. FEBS Lett 1997;411:313-316. (from Pfam)

Date:

2024-10-16

Date:

2020-10-26

All proteins in this family for which functions are known are single-stranded DNA binding proteins that function in many processes including transcription, repair, replication and recombination. Members encoded between genes for ribosomal proteins S6 and S18 should be annotated as primosomal protein N (PriB). Forms in gamma-protoeobacteria are much shorter and poorly recognized by this model. Additional members of this family include phage proteins. Eukaryotic members are organellar proteins.

Gene:

ssb

Date:

2021-05-12