Protein Family Models

Transposase proteins are necessary for efficient DNA transposition. Contains transposases for IS204 (Swiss:Q50911) [1], IS1001 (Swiss:Q06126) [2], IS1096 (Swiss:Q50440) [3] and IS1165 Swiss:Q48788 [4]. [1]. 8196545. Isolation and characterization of IS31831, a transposable element from Corynebacterium glutamicum. Vertes AA, Inui M, Kobayashi M, Kurusu Y, Yukawa H;. Mol Microbiol 1994;11:739-746. [2]. 8093238. Characterization of IS1001, an insertion sequence element of Bordetella parapertussis. van der Zee A, Agterberg C, van Agterveld M, Peeters M, Mooi FR;. J Bacteriol 1993;175:141-147. [3]. 1660454. A novel transposon trap for mycobacteria: isolation and characterization of IS1096. Cirillo JD, Barletta RG, Bloom BR, Jacobs WR Jr;. J Bacteriol 1991;173:7772-7780. [4]. 1325060. Isolation and characterization of IS1165, an insertion sequence of Leuconostoc mesenteroides subsp. cremoris and other lactic acid bacteria. Johansen E, Kibenich A;. Plasmid 1992;27:200-206. (from Pfam)

Date:

2024-10-16

Fatty acid desaturases are enzymes that catalyse the insertion of a double bond at the delta position of fatty acids. There seem to be two distinct families of fatty acid desaturases which do not seem to be evolutionary related: Family 1 composed of Stearoyl-CoA desaturases (SCD) [1,2] and Family 2 composed of Bacterial fatty acid desaturases, Plant stearoyl-acyl-carrier-protein desaturase [3] and Cyanobacterial DesA [4]. Members of this entry are ER integral membrane proteins that share the same mushroom-shaped fold consisting of four transmembrane helices (TM1-TM4) which anchor them to the membrane, capped by a cytosolic domain containing a unique 9-10 histidine- coordinating di metal (di-iron) catalytic centre [5,6]. The structure of mouse stearoyl-CoA desaturase (SDC) revealed that TM2 and TM4 are longer than TM1 and TM3 and protrude into the cytosolic domain, providing three of the nine histidine residues that coordinate the two metal ions, while the other histidine residues are provided by the soluble domain in this enzyme [5]. [1]. 8861937. Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins. Lindqvist Y, Huang W, Schneider G, Shanklin J;. EMBO J 1996;15:4081-4092. [2]. 2570068. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. Kaestner KH, Ntambi JM, Kelly TJ Jr, Lane MD;. J Biol Chem. 1989;264:14755-14761. [3]. 2006187. Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs. Shanklin . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

Gene:

desA

Date:

2023-06-30

acyl-CoA desaturase removes two hydrogen atoms from a fatty acid, creating a carbon/carbon double bond; similar to acyl-CoA delta(9) desaturase and acyl-CoA delta(11) desaturase; may also contain a transposase domain

Date:

2020-08-10