Protein Family Models

This family is found primarily in bacterial surface antigens, normally as variable number repeats at the N-terminus. The C-terminus of these proteins is normally represented by Pfam:PF01103. The alignment centres on a -GY- or -GF- motif. Some members of this family are found in the mitochondria. It is predicted to have a mixed alpha/beta secondary structure. (from Pfam)

Date:

2024-08-14

The Omp85 protein superfamily contains bacterial outer membrane proteins, which can function as protein translocases or as membrane protein assembly factors [1]. The family includes the membrane bound beta barrel of proteins such as BamA and TamA from E. coli. [1]. 25101071. A comprehensive analysis of the Omp85/TpsB protein superfamily structural diversity, taxonomic occurrence, and evolution. Heinz E, Lithgow T;. Front Microbiol. 2014;5:370. (from Pfam)

Date:

2024-10-16

outer membrane protein assembly factor BamA is part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane

Date:

2021-01-15

Members of this protein family are the YaeT protein of the YaeT/YfiO complex for assembling proteins into the outer membrane of Gram-negative bacteria. This protein is similar in sequence and function to a non-essential paralog, YtfM, that is also in the Omp85 family. Members of this family typically have five tandem copies of the surface antigen variable number repeat (PF07244), followed by an outer membrane beta-barrel domain (PF01103), while the YtfM family typically has a single PF07244 repeat.

Gene:

bamA

Date:

2024-06-27