Protein Family Models

This family of bacterial proteins includes a sodium-translocating NADH-ubiquinone oxidoreductase (i.e. a respiration linked sodium pump). In Vibrio cholerae, it negatively regulates the expression of virulence factors through inhibiting (by an unknown mechanism) the transcription of the transcriptional activator ToxT [1]. The family also includes proteins involved in nitrogen fixation, RnfD and RnfE. The similarity of these proteins to NADH-ubiquinone oxidoreductases was previously noted [2]. [1]. 10077658. Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae. Hase CC, Mekalanos JJ;. Proc Natl Acad Sci U S A 1999;96:3183-3187. [2]. 9154934. Membrane localization, topology, and mutual stabilization of the rnfABC gene products in Rhodobacter capsulatus and implications for a new family of energy-coupling NADH oxidoreductases. Kumagai H, Fujiwara T, Matsubara H, Saeki K;. Biochemistry 1997;36:5509-5521. (from Pfam)

Date:

2024-10-16

The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the A subunit.

Date:

2024-06-26

electron transport complex subunit D is part of the Rnf complex that functions as a redox-driven ion pump, coupling an oxidoreduction process to the translocation of Na+ across the cell membrane

Date:

2017-03-02