Protein Family Models

This entry represents the C-terminal domain of RapZ which belongs to the Rhodanese-Phosphatase superfamily. It has been shown to bind multiple ligands as part of the regulation of glucosamine-6-phosphate (GlcN6P) levels, which is a precursor to the bacterial cell wall polymer peptidoglycan. Assignment to the greater Rhodanese-Phosphatase superfamily has led to the prediction that, as part of this regulation, it functions as a sugar phosphorylation-dephosphorylation switch [1]. [1]. 36968430. New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts. Burroughs AM, Aravind L;. NAR Genom Bioinform. 2023;5:lqad029. (from Pfam)

Date:

2024-10-16

This entry represents the N-terminal P-loop kinase domain of RNase adapter protein RapZ and related proteins. RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism [1-3]. It is a RNA-binding protein that recruits the major endoribonuclease RNase E to sRNAs GlmZ [1,2]. [1]. 23475961. Targeted decay of a regulatory small RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA. Gopel Y, Papenfort K, Reichenbach B, Vogel J, Gorke B;. Genes Dev. 2013;27:552-564. [2]. 28977623. Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism. Gonzalez GM, Durica-Mitic S, Hardwick SW, Moncrieffe MC, Resch M, Neumann P, Ficner R, Gorke B, Luisi BF;. Nucleic Acids Res. 2017;45:10845-10860. [3]. 36968430. New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts. Burroughs AM, Aravind L;. NAR Genom Bioinform. 2023;5:lqad029. (from Pfam)

Date:

2024-10-16

RNase adapter RapZ (also known as YhbJ) interacts with the small RNAs GlmY and GlmZ to modulate GlmS synthesis

Date:

2020-05-20

Inactivates the glmS upregulator glmZ

Gene:

rapZ

Date:

2021-07-22