Protein Family Models

This domain is found at the C-terminal end of Nucleoid occlusion factor SlmA from Escherichia coli and similar transcriptional repressors from proteobacteria. SlmA is required for the nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. It is organised into two domains, a small N-terminal Pfam:PF00440 and a C-terminal domain (this entry). This domain shows an all-alpha configuration. This region mediates dimerisation [1]. Paper describing PDB structure 3nxc. [1]. 21113127. Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check. Tonthat NK, Arold ST, Pickering BF, Van Dyke MW, Liang S, Lu Y, Beuria TK, Margolin W, Schumacher MA;. EMBO J. 2011;30:154-164. Paper describing PDB structure 3vuq. [2]. 23408580. Structure and function of a TetR family transcriptional regulator, SbtR, from thermus thermophilus HB8. Agari Y, Sakamoto K, Yutani K, Kuramitsu S, Shinkai A;. Proteins. 2013;81:1166-1178. Paper describing PDB structure 4gck. [3]. 23754405. SlmA forms a higher-order structure on DNA that inhibits cytokinetic Z-ring formation over the nucleoid. Tonthat NK, Milam SL, Chinnam N, Whitfill T, Margolin W, Schumacher MA;. Proc Natl Acad Sci U S A. 2013;110:10586-10591. Paper describing PDB structure 5haw. [4]. 27091999. Structures of the nucleoid occlusion protein SlmA bound to DNA and the C-terminal domain of the cytoskeletal protein FtsZ. Schumacher MA, Zeng W;. Proc Natl Acad Sci U S A. 2016;113:4988-4993. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

nucleoid occlusion protein SlmA helps mediate nucleoid occlusion, which prevents chromosome fragmentation by binding FtsZ and inhibiting Z-ring formation over the nucleoid

Date:

2023-02-28

FtsZ binding protein; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly

Gene:

slmA

Date:

2021-08-31