Protein Family Models

Members of this family belong to glycosyltransferase family 9 [1]. Lipopolysaccharide is a major component of the outer leaflet of the outer membrane in Gram-negative bacteria. It is composed of three domains; lipid A, Core oligosaccharide and the O-antigen. All of these enzymes transfer heptose to the lipopolysaccharide core. [1]. 9334165. A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities. Campbell JA, Davies GJ, Bulone V, Henrissat B;. Biochem J 1997;326:929-939. [2]. 9446588. Enzymatic synthesis of lipopolysaccharide in Escherichia coli. Purification and properties of heptosyltransferase I. Kadrmas JL, Raetz CR;. J Biol Chem 1998;273:2799-2807. (from Pfam)

Date:

2024-10-16

This family consists of examples of ADP-heptose:LPS heptosyltransferase II, an enzyme of LPS inner core region biosynthesis. LPS, composed of lipid A, a core region, and O antigen, is found in the outer membrane of Gram-negative bacteria.

Gene:

waaF

Date:

2024-06-11

ADP-heptose--LPS heptosyltransferase RfaF (also known as WaaF) is a glycosyltransferase involved in the synthesis of the inner core region of lipopolysaccharide

Date:

2019-06-19

Catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core

Gene:

rfaF

Date:

2021-10-01