Protein Family Models

YeeE (TsuA) and YedE are paralogous transporters in E. coli that differ substantially. Both show evidence of an internal duplication, with the strongest similarity being between the N-terminal half of YeeE and the C-terminal half of YedE. YeeE, with partner sulfurtransferase YeeD (TsuB), are involved in thiosulfate utilization. Some members of the broader family are selenoproteins, which is observed only rarely for transporter families.

Date:

2024-10-16

YeeE/YedE family protein similar to Escherichia coli proteins YeeE and YedE, which are membrane proteins that constitute transport components for sulfur-containing compounds

Date:

2016-11-25

Members of this family are predicted multiple membrane-spanning proteins, and therefore thought likely to be transporters. It appears that all species whose genomes encode a member of this family produce selenocysteine-containing enzymes, typically formate dehydrogenase. The family member from Campylobacter jejuni was show to be essential for formate dehydrogenase (a selenocysteine-containing enzyme) expression and activity, and so it was named a formate dehydrogenase accessory protein, FdhT. Note that this family is related to (but distinct from) that of TIGR04112, which is similarly restricted to species with pathways for selenium incorporation.

Gene:

yedE

Date:

2020-10-26