Protein Family Models

This family consists of several different short Staphylococcal proteins known as the phenol-soluble modulin beta proteins. The family contains SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic activity (SLUSH), phenotypically similar to the delta-hemolysin of S. aureus [1]. Gonococcal growth inhibitor from Staphylococcus act on the cytoplasmic membrane of the gonococcal cell causing cytoplasmic leakage and, eventually, death [2]. [1]. 8975897. Synergistic hemolytic activity of Staphylococcus lugdunensis is mediated by three peptides encoded by a non-agr genetic locus. Donvito B, Etienne J, Denoroy L, Greenland T, Benito Y, Vandenesch F;. Infect Immun 1997;65:95-100. [2]. 3134553. Site of action of a gonococcal growth inhibitor produced by Staphylococcus haemolyticus. Frenette M, Beaudet R, Bisaillon JG, Portelance V;. J Med Microbiol 1988;26:199-204. Paper describing PDB structure 5kgz. [3]. 27525453. Solution Structures of Phenol-Soluble Modulins alpha1, alpha3, and beta2, Virulence Factors from Staphylococcus aureus. Towle KM, Lohans CT, Miskolzie M, Acedo JZ, van Belkum MJ, Vederas JC;. Biochemistry. 2016;55:4798-4806. (from Pfam)

Date:

2024-10-16