Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
2'-5' RNA ligase family protein
This family contains proteins related to Pfam:PF02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity. (from Pfam)
Members of this family are bacterial and archaeal RNA ligases that are able to ligate tRNA half molecules containing 2',3'-cyclic phosphate and 5' hydroxyl termini to products containing the 2',5' phosphodiester linkage. Each member of this family contains an internal duplication, each of which contains an HXTX motif that defines the family. The structure of a related protein is known [1]. They belong to the 2H phosphoesterase superfamily [2]. They share a common active site, characterised by two conserved histidines, with vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins. [1]. 11080166. Structure and mechanism of activity of the cyclic. phosphodiesterase of Appr>p, a product of the tRNA splicing. reaction.. Hofmann A, Zdanov A, Genschik P, Ruvinov S, Filipowicz W,. Wlodawer A;. EMBO J 2000;19:6207-6217.. [2]. 12466548. Detection of novel members, structure-function analysis and. evolutionary classification of the 2H phosphoesterase. superfamily.. Mazumder R, Iyer LM, Vasudevan S, Aravind L;. Nucleic Acids Res 2002;30:5229-5243. (from Pfam)
YjcG family protein
YjcG family protein similar to Bacillus subtilis phosphoesterase YjcG, a putative 2'-5' RNA Ligase
hypothetical protein
Filter your results:
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on