Protein Family Models

This entry represents the extended beta-sheet domain (EBD, also known as DUF1975) of UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit [1,2]. GtfA is the core enzyme of the OGT complex, which also includes the co-activator GtfB, to glycosylate the serine-rich repeat (SRR) of adhesin PsrP in Streptococcus pneumoniae, a protein involved in the infection and pathogenesis [1,2]. The function of this domain is not clear. [1]. 26884191. Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein. Chen Y, Seepersaud R, Bensing BA, Sullam PM, Rapoport TA;. Proc Natl Acad Sci U S A. 2016;113:E1190-E1199. [2]. 24936067. Structure of a novel O-linked N-acetyl-D-glucosamine (O-GlcNAc) transferase, GtfA, reveals insights into the glycosylation of pneumococcal serine-rich repeat adhesins. Shi WW, Jiang YL, Zhu F, Yang YH, Shao QY, Yang HB, Ren YM, Wu H, Chen Y, Zhou CZ;. J Biol Chem. 2014;289:20898-20907. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. (from Pfam)

Date:

2024-08-14

TIGR02918 family protein

Date:

2017-03-02

Members of this protein family are found only in Gram-positive bacteria of the Firmicutes lineage, including several species of Staphylococcus, Streptococcus, and Lactobacillus. Members are associated with glycosylation of serine-rich glycoproteins exported by the accessory Sec system.

Gene:

gtfA

Date:

2021-10-20