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ArsC/Spx/MgsR family protein
Members of this family include both regulatory proteins such as Spx or MgsR and the arsenate reductase ArsC. Some ArsC proteins are selenoproteins.
Spx/MgsR family RNA polymerase-binding regulatory protein
Spx/MgsR family RNA polymerase-binding regulatory protein similar to Bacillus subtilis MgsR that regulates transcription of a subregulon within the general stress response; belongs to the thioredoxin superfamily
Members of this family regulate transcription by binding the alpha subunit of RNA polymerase, and affecting its binding of DNA, rather than by binding DNA directly. Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B. Members are related to the arsenate reductase ArsC.
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