Protein Family Models for Protein (Select 488138628) - Protein Family Models

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Links from Protein

Items: 7

Select item 4110981.

aminotransferase class V-fold PLP-dependent enzyme

This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF012488.5
Method:: HMM

Select item 3896442.

new record, indexing in progress

Family Accession:

Select item 3887103.

new record, indexing in progress

Family Accession:

Select item 3481064.

new record, indexing in progress

Family Accession:

Select item 1421585.

IscS subfamily cysteine desulfurase

This HMM represents IscS, one of several cysteine desulfurases from a larger protein family designated (misleadingly, in this case) class V aminotransferases. IscS is one of at least 6 enzymes characteristic of the IscSUA-hscAB-fsx system of iron-sulfur cluster assembly. Scoring almost as well as proteobacterial sequences included in the model are mitochondrial cysteine desulfurases, apparently from an analogous system in eukaryotes. The sulfur, taken from cysteine, may be used in other systems as well, such as tRNA base modification and biosynthesis of other cofactors.

GO Terms:

Molecular Function:: pyridoxal phosphate binding (GO:0030170)

Molecular Function:: cysteine desulfurase activity (GO:0031071)

Biological Process:: [2Fe-2S] cluster assembly (GO:0044571)

Date:: 2024-06-24

Family Accession:: TIGR02006.1
Method:: HMM

Select item 555836.

IscS subfamily cysteine desulfurase

IscS subfamily cysteine desulfurase is a pyridoxal-5'-phoshate dependent enzyme that catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine