Protein Family Models for Protein (Select 487717641) - Protein Family Models

Select item 4158581.

NTF2-like N-terminal transpeptidase domain-containing protein

The structure of this domain from MecA is known [1] Swiss:Q53707 and is found to be similar to that found in NTF2 Pfam:PF02136. This domain seems unlikely to have an enzymatic function, and its role remains unknown. [1]. 12389036. Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus. Lim D, Strynadka NC;. Nat Struct Biol 2002;9:870-876. (from Pfam)

GO Terms:

Biological Process:: response to antibiotic (GO:0046677)

Date:: 2024-10-16

Family Accession:: NF017073.5
Method:: HMM

Select item 4153842.

Penicillin-binding Protein dimerisation domain

This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered 'sugar tongs' structure. (from Pfam)

GO Terms:

Molecular Function:: penicillin binding (GO:0008658)

Date:: 2024-08-14

Family Accession:: NF015662.5
Method:: HMM

Select item 4110633.

penicillin-binding transpeptidase domain-containing protein

The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family. [1]. 8605631. X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O. Nat Struct Biol 1996;3:284-289. (from Pfam)

GO Terms:

Molecular Function:: penicillin binding (GO:0008658)

Date:: 2024-10-16

Family Accession:: NF013100.5
Method:: HMM

Select item 3936854.

new record, indexing in progress

Family Accession:

Select item 3897315.

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Family Accession:

Select item 3891706.

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Family Accession:

Select item 3499597.

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Family Accession:

Select item 3496558.

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Family Accession:

Select item 3467839.

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Family Accession:

Select item 16452910.

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Family Accession:

Select item 16432311.

PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA

Gene:: mecA

GO Terms:

Molecular Function:: penicillin binding (GO:0008658)

Biological Process:: response to antibiotic (GO:0046677)

Date:: 2021-07-12

Family Accession:: NF000409.1
Method:: HMM

Select item 11206212.

penicillin-binding transpeptidase domain-containing protein

penicillin-binding transpeptidase domain-containing protein such as PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA; in the presence of beta-lactam antibiotics, MRSA cells produce this unique penicillin-binding protein (PBP) MecA in excessively large amounts and can still proliferate, while all the normal PBPs are inactivated

Date:: 2017-02-03

Family Accession:: 11649868
Method:: Sparcle

Select item 3503013.

PBP2a family beta-lactam-resistant peptidoglycan transpeptidase

Gene:: mec

GO Terms:

Molecular Function:: penicillin binding (GO:0008658)

Biological Process:: response to antibiotic (GO:0046677)

Date:: 2021-07-12

Family Accession:: NF000237.1
Method:: HMM

Select item 3377914.

new record, indexing in progress

Family Accession:

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