Protein Family Models

vWA (von Willebrand factor type A) domain-containing protein may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and immune defenses

Date:

2024-11-05

Date:

2024-08-14

Date:

2024-08-14

This domain is functionally uncharacterised. This domain represents the C-terminal of the uncharacterized protein YfbK. This domain is about 180 amino acids in length. This domain is found at the C-terminal of Pfam:PF00092. (from Pfam)

Date:

2024-08-14

This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with Pfam:PF00092. There are two conserved sequence motifs: STF and DVD. There are two completely conserved residues (E and N) that may be functionally important. In hemostasis, platelet adhesion to the damaged vessel wall is mediated by several proteins, including von Willebrand factor. In solution vWF becomes immobilized via its A3 domain on the fibrillar collagen of the vessel wall and acts as an intermediary between collagen and the platelet receptor glycoprotein Ibalpha (GPIbalpha), which is the only platelet receptor that does not require prior activation for bond formation. [1]. 18786007. Function of von Willebrand factor in haemostasis and thrombosis. Reininger AJ;. Haemophilia. 2008;14:11-26. (from Pfam)

Date:

2024-12-30

Date:

2024-08-14