Protein Family Models

Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N-terminus has been previously erroneously described as being ATP-binding [1]. Recent work shows that it is similar to eukaryotic G-proteins and that it is a GTPase [2]. [1]. 8407793. Characterization of the ferrous iron uptake system of. Escherichia coli.. Kammler M, Schon C, Hantke K;. J Bacteriol 1993;175:6212-6219.. [2]. 12446835. The membrane protein FeoB contains an intramolecular G protein. essential for Fe(II) uptake in bacteria.. Marlovits TC, Haase W, Herrmann C, Aller SG, Unger VM;. Proc Natl Acad Sci U S A 2002;99:16243-16248. (from Pfam)

Date:

2024-08-14

This region in the nucleoside transporter proteins are responsible for determining nucleoside specificity in the human CNT1 and CNT2 proteins (e.g Swiss:O00337) [1]. In the FeoB proteins (e.g. Swiss:O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this region is likely to be more general than just nucleoside specificity [2]. This family may represent the pore and gate, with a wide potential range of specificity. Hence its name 'Gate'. [1]. 10455109. Identification of amino acid residues responsible for the. pyrimidine and purine nucleoside specificities of human. concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.. Loewen SK, Ng AM, Yao SY, Cass CE, Baldwin SA, Young JD;. J Biol Chem 1999;274:24475-24484.. [2]. 12781516. Is the bacterial ferrous iron transporter FeoB a living fossil?.. Hantke K;. Trends Microbiol 2003;11:192-195. (from Pfam)

Date:

2024-08-14

Escherichia coli has an iron(II) transport system (feo) which may make an important contribution to the iron supply of the cell under anaerobic conditions [1]. FeoB has been identified as part of this transport system. FeoB is a large 700-800 amino acid integral membrane protein. The N terminus contains a P-loop motif suggesting that iron transport may be ATP dependent [1]. [1]. 8407793. Characterization of the ferrous iron uptake system of. Escherichia coli.. Kammler M, Schon C, Hantke K;. J Bacteriol 1993;175:6212-6219. (from Pfam)

Date:

2024-08-14

This HMM identifies the P-loop-containing domain of large numbers of GTPases with ribosome-associated functions, including many involved in ribosome maturation (Der, Era, etc), ribosome rescue (HflX), and protein translation (InfB, Tuf, PrfC).

Date:

2024-08-14

ferrous iron transporter B is part of an Fe(2+) uptake system that is probably driven by GTP hydrolysis

Date:

2024-08-20