Protein Family Models

Family members are bacterial microcin-V peptides MccV, also known as colicin V. MccV was the first antibiotic substance reported to be produced by E. coli. This antibacterial agent was initially named colicin V (ColV). However, on account of several characteristics (low molecular mass, non-inducible production, and dedicated export system), it became classified within the microcins. The structural gene cvaC, encodes the 103-aa MccV precursor. The dedicated export system of MccV has been well characterized and involves two genes that form the second operon. The MccV protein has an N-terminal double glycine motif which precedes the cleavage site for the precursor protein [1]. [1]. 17653356. Microcins, gene-encoded antibacterial peptides from enterobacteria. Duquesne S, Destoumieux-Garzon D, Peduzzi J, Rebuffat S;. Nat Prod Rep. 2007;24:708-734. (from Pfam)

Date:

2024-10-16

MccV domain-containing protein

Date:

2019-03-21

Colicin V is a bacteriocin commonly found on, and used as a marker for, virulence plasmids that produce aerobactin, a siderophore.

Gene:

cvaC

Date:

2019-10-24