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Items: 6

1.

histidine phosphatase family protein

The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members. [1]. 18092946. The histidine phosphatase superfamily: structure and function. Rigden DJ;. Biochem J. 2008;409:333-348. (from Pfam)

Date:
2024-10-16
Family Accession:
NF012521.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

adenosylcobalamin/alpha-ribazole phosphatase

GO Terms:
Biological Process:
cobalamin biosynthetic process (GO:0009236)
Molecular Function:
alpha-ribazole phosphatase activity (GO:0043755)
Date:
2021-10-28
Family Accession:
NF011580.0
Method:
HMM
5.

adenosylcobalamin/alpha-ribazole phosphatase

adenosylcobalamin/alpha-ribazole phosphatase catalyzes the conversion of adenosylcobalamin 5'-phosphate to adenosylcobalamin (vitamin B12), which is involved in the assembly of the nucleotide loop of cobalamin; also catalyzes the hydrolysis of the phospho group from alpha-ribazole 5'-phosphate to form alpha-ribazole

Date:
2019-09-06
Family Accession:
10794108
Method:
Sparcle
6.

alpha-ribazole phosphatase

Members of this protein family include the known CobC protein of Salmonella and Eschichia coli species, and homologous proteins found in cobalamin biosynthesis regions in other bacteria. This protein is alpha-ribazole phosphatase (EC 3.1.3.73) and, like many phosphatases, can be closely related in sequence to other phosphatases with different functions. Close homologs excluded from this model include proteins with duplications, so this model is built in -g mode to suppress hits to those proteins.

Gene:
cobC
GO Terms:
Biological Process:
cobalamin biosynthetic process (GO:0009236)
Molecular Function:
alpha-ribazole phosphatase activity (GO:0043755)
Date:
2024-02-27
Family Accession:
TIGR03162.1
Method:
HMM
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