Protein Family Models

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda integrase catalytic core. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a site-specific recombination synapse. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

Date:

2024-10-16

IpuA (integrase-like proteins in uropathogenic E. coli. A), a DNA-inverting tyrosine recombinase, toggles the ON/OFF status of the neighboring for the phase-variable autotransporter UpaE. It is also one of four DNA invertases, out of five in the model uropathogenic Escherichia coli strain CFT073, that toggle the type 1 pilus fim phase switch.

Gene:

ipuA

Date:

2020-07-21

Date:

2022-02-18

Date:

2022-02-18