Protein Family Models for Protein (Select 447086634) - Protein Family Models

Select item 4110891.

This family of dehydrogenases act on aldehyde substrates. Members use NADP as a cofactor. The family includes the following members: The prototypical members are the aldehyde dehydrogenases Swiss:P00352 EC:1.2.1.3. Succinate-semialdehyde dehydrogenase Swiss:P25526 EC:1.2.1.16. Lactaldehyde dehydrogenase Swiss:P25553 EC:1.2.1.22. Benzaldehyde dehydrogenase Swiss:P43503 EC:1.2.1.28. Methylmalonate-semialdehyde dehydrogenase Swiss:Q02252 EC:1.2.1.27. Glyceraldehyde-3-phosphate dehydrogenase Swiss:P81406 EC:1.2.1.9. Delta-1-pyrroline-5-carboxylate dehydrogenase Swiss:P30038 EC: 1.5.1.12. Acetaldehyde dehydrogenase Swiss:P17547 EC:1.2.1.10. Glutamate-5-semialdehyde dehydrogenase Swiss:P07004 EC:1.2.1.41. This family also includes omega crystallin Swiss:P30842 an eye lens protein from squid and octopus that has little aldehyde dehydrogenase activity. [1]. 9195888. Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. Steinmetz CG, Xie P, Weiner H, Hurley TD;. Structure 1997;5:701-711. (from Pfam)

GO Terms:

Molecular Function:: oxidoreductase activity (GO:0016491)

Date:: 2024-10-16

Family Accession:: NF012398.5
Method:: HMM

Select item 3886442.

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Family Accession:

Select item 3465953.

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Family Accession:

Select item 1868834.

aminobutyraldehyde dehydrogenase

GO Terms:

Molecular Function:: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)

Date:: 2021-10-15

Family Accession:: NF010000.0
Method:: HMM

Select item 1479635.

aminobutyraldehyde dehydrogenase

Members of this protein family are Aminobutyraldehyde dehydrogenase (EC 1.2.1.19), also called 1-pyrroline dehydrogenase and gamma-aminobutyraldehyde dehydrogenase. This enzyme can follow putrescine aminotransferase (EC 2.6.1.82) for a two-step conversion of putrescine to gamma-aminobutyric acid (GABA). The member from Escherichia coli is characterized as a homotetramer that binds one NADH per momomer. This enzyme belongs to the medium-chain aldehyde dehydrogenases, and is quite similar in sequence to the betaine aldehyde dehydrogenase (EC 1.2.1.8) family.

Gene:: patD

GO Terms:

Biological Process:: putrescine catabolic process (GO:0009447)

Molecular Function:: aminobutyraldehyde dehydrogenase (NAD+) activity (GO:0019145)

Molecular Function:: NAD binding (GO:0051287)

Date:: 2024-05-30

Family Accession:: TIGR03374.1
Method:: HMM

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