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virulence-associated effector SrfA
SrfA (SsrAB regulated factor A) from Salmonella enterica is a secreted effector, although the system responsible for secretion is not known. It is encoded in ssrABC operon that has counterparts in many pathogenic proteobacteria. SrfA alone can alter the function of the NF-kappa-B system in macrophages, affecting levels of inflammatory response. Work on related proteins suggests SrfA, SfrB, and SfrC form a complex and can work cooperatively as an effector toxin.
SrfA family protein
The virulence factor SrfA (SsrAB regulated factor A) from Salmonella enterica is a secreted effector. The mechanism of secretion is not known. SrfA belongs to a set of three SsrAB regulated factors, along with SrfB and SrfC. Operons related to srfABC are widely distributed in proteobacteria, suggesting coordinated action, and the three proteins appear able to form a complex.
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