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Links from Protein

Items: 4

1.

type II toxin-antitoxin system CcdA family antitoxin

This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein [1]. [1]. 10196173. Interactions of CcdB with DNA gyrase. Inactivation of Gyra, poisoning of the gyrase-DNA complex, and the antidote action of CcdA. Bahassi EM, O'Dea MH, Allali N, Messens J, Gellert M, Couturier M;. J Biol Chem 1999;274:10936-10944. (from Pfam)

Date:
2024-10-16
Family Accession:
NF019009.5
Method:
HMM
2.
new record, indexing in progress
Family Accession:
3.
new record, indexing in progress
Family Accession:
4.

similar to antitoxin VapB3

protein similar to antitoxin VapB3

Date:
2017-03-02
Family Accession:
10009188
Method:
Sparcle
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