Protein Family Models

This DDE domain is found in a wide variety of transposases including those found in IS240, IS26, IS6100 and IS26. (from Pfam)

Date:

2024-08-14

Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1]. [1]. 7801124. Crystal structure of the catalytic domain of HIV-1 integrase:. similarity to other polynucleotidyl transferases [see comments]. Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies. DR;. Science 1994;266:1981-1986. (from Pfam)

Date:

2024-08-14

IS6 family transposase binds to the end of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism

Date:

2023-02-21

IS257 and IS431 are very closely related insertion sequences, sufficiently so that they may be considered isoforms. The isoform regularly found in Staphylococcus aureus flanking the mecA gene is typically designated IS431.

Date:

2023-10-03

Date:

2021-03-03

Date:

2019-09-10