Protein Family Models

This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 Swiss:P23909 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2 Swiss:P94545 [1]. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity [2]. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity. [1]. 10431172. Smr: a bacterial and eukaryotic homologue of the C-terminal region of the MutS2 family. Moreira D, Philippe H;. Trends Biochem Sci 1999;24:298-300. [2]. 12730195. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. Watanabe N, Wachi S, Fujita T;. J Biol Chem. 2003;278:26102-26110. (from Pfam)

Date:

2024-10-16

Smr/MutS family endonuclease similar to Escherichia coli DNA endonuclease SmrA (also called YdaL) that is a stand-alone small MutS-related protein with DNA binding and endonuclease activity

Date:

2021-08-24

YdaL is a small endonuclease with homology to the C-terminal domain found in the endonuclease MutS2, but not found in the related mismatch repair protein MutS. The biological role of this endonuclease is not yet known. As one of two Small MutS2-Related proteins in E. coli, This protein was designated SmrA by Gui, et al. (PMID:21276852). The term SMR is much better known for describing a large family of Small Multidrug Resistance (SMR) efflux transporters, but in that context is used with three capital letters.

Gene:

smrA

Date:

2020-10-26