Protein Family Models

ESPR (Extended Signal Peptide Region) is found in type V secretion system (T5SS) system proteins. Many such proteins are virulence factors, such autotransporter adhesins YapH (Yersinia pestis), FdeC (Escherhical coli), and BapA (Bartonella henselae), and autotransporter toxins such as VacA (Helicobacter pylori), SepA (Shigella flexneri), and Vat (Escherichia coli).

Date:

2024-08-14

This entry represents two copies of a fourteen residue repeat that makes up the head domain of bacterial haemagglutinins and invasins. (from Pfam)

Date:

2024-08-14

This short motif is found in invasins and haemagglutinins, normally associated with (Pfam:PF05658). (from Pfam)

Date:

2024-08-14

This region represents the C-terminal 120 amino acids of a family of surface-exposed bacterial proteins. YadA, an adhesin from Yersinia, was the first member of this family to be characterised. UspA2 from Moraxella was second. The Eib immunoglobulin-binding proteins from E. coli were third, followed by the DsrA proteins of Haemophilus ducreyi and others. These proteins are homologous at their C-terminal and have predicted signal sequences, but they diverge elsewhere. The C-terminal 9 amino acids, consisting of alternating hydrophobic amino acids ending in F or W, comprise a targeting motif for the outer membrane of the Gram negative cell envelope. This region is important for oligomerisation [1]. [1]. 11705900. Nonimmune binding of human immunoglobulin A (IgA) and IgG Fc by. distinct sequence segments of the EibF cell surface protein of. Escherichia coli.. Sandt CH, Hill CW;. Infect Immun 2001;69:7293-7303.. [2]. 11080146. Structure and sequence analysis of Yersinia YadA and Moraxella. UspAs reveal a novel class of adhesins.. Hoiczyk E, Roggenkamp A, Reichenbecher M, Lupas A, Heesemann J;. EMBO J 2000;19:5989-5999. (from Pfam)

Date:

2024-08-14

Trimeric autotransporter EhaG is described as a positional ortholog of UpaG. It is about 78% identical in amino acid sequence overall, but about 88% identical in the C-terminal half.

Gene:

ehaG

Date:

2020-09-08