This domain is found at the N-terminus of the Type II secretion secretion system protein E (GspE) and type IV pilus extensin ATPase PilB and near the C-terminus of the glycosyltransferase NfrB. A variant of this domain, called MshEN, binds cyclic di-GMP [4,6,7], which modulates the activity of the respective protein. The structure of this domain is now known [1,2,4]. [1]. 15843017. The X-ray structure of the type II secretion system complex formed by the N-terminal domain of EpsE and the cytoplasmic domain of EpsL of Vibrio cholerae. Abendroth J, Murphy P, Sandkvist M, Bagdasarian M, Hol WG;. J Mol Biol. 2005;348:845-855. Paper describing PDB structure 2d27. [2]. 16162504. Structure and function of the XpsE N-terminal domain, an essential component of the Xanthomonas campestris type II secretion system. Chen Y, Shiue SJ, Huang CW, Chang JL, Chien YL, Hu NT, Chan NL;. J Biol Chem. 2005;280:42356-42363. [3]. 14600218. Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier MH Jr;. Microbiology. 2003;149:3051-3072. Paper describing PDB structure 5htl. [4]. 27578558. Nucleotide binding by the widespread high-affinity cyclic di-GMP receptor MshEN domain. Wang YC, Chin KH, Tu ZL, He J, Jones CJ, Sanchez DZ, Yildiz FH, Galperin MY, Chou SH;. Nat Commun. 2016;7:12481. Paper describing PDB structure 6ejf. [5]. 30232337. Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly. Collins R, Karuppiah V, Siebert CA, Dajani R, Thistlethwaite A, Derrick JP;. Sci Rep. 2018;8:14022. [6]. 3490. TRUNCATED at 1650 bytes (from Pfam)
- Date:
- 2024-10-16