Protein Family Models

This family contains integral membrane proteins that are related to Drosophila rhomboid protein Swiss:P20350. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease [2][3][4] (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite [5]. [1]. 2110920. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Bier E, Jan LY, Jan YN;. Genes Dev 1990;4:190-203. [2]. 11672525. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Urban S, Lee JR, Freeman M;. Cell 2001;107:173-182. [3]. 12620104. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L;. Genome Biol 2003;4:R19. [4]. 15684070. Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Urban S, Wolfe MS;. Proc Natl Acad Sci U S A. 2005;102:1883-1888. [5]. 15753289. A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by Toxoplasma. Brossier F, Jewett TJ, Sibley LD, Urban S;. Proc Natl Acad Sci U S A. 2005;102:4146-4151. (from Pfam)

Date:

2024-10-16

rhomboid family protein may be an intramembrane serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors, or an inactive rhomboid protein that lacks the conserved active sites and has no peptidase activity

Date:

2024-08-02