Protein Family Models

Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit [1,2]. [1]. 23539602. Structure of the integral membrane protein CAAX protease Ste24p. Pryor EE Jr, Horanyi PS, Clark KM, Fedoriw N, Connelly SM, Koszelak-Rosenblum M, Zhu G, Malkowski MG, Wiener MC, Dumont ME;. Science. 2013;339:1600-1604. [2]. 23539603. The structural basis of ZMPSTE24-dependent laminopathies. Quigley A, Dong YY, Pike AC, Dong L, Shrestha L, Berridge G, Stansfeld PJ, Sansom MS, Edwards AM, Bountra C, von Delft F, Bullock AN, Burgess-Brown NA, Carpenter EP;. Science. 2013;339:1604-1607. (from Pfam)

Date:

2024-10-16

heat shock protein HtpX, an integral membrane metallopeptidase, plays a central role in protein quality control by preventing the accumulation of misfolded proteins in the membrane

Date:

2023-03-08

Gene:

htpX

Date:

2021-08-12