Protein Family Models

This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers [1]. Note that many family members are hypothetical proteins. [1]. 11803016. C4-dicarboxylate carriers and sensors in bacteria. Janausch IG, Zientz E, Tran QH, Kroger A, Unden G;. Biochim Biophys Acta 2002;1553:39-56. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

anaerobic C4-dicarboxylate transporter DcuC is responsible for the transport of C4-dicarboxylates during anaerobic growth

Date:

2015-10-16

Functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate

Gene:

dcuC

Date:

2021-09-10

These proteins are members of the C4-dicarboxylate Uptake C (DcuC) Family (TC 2.A.61). The only functionally characterized member of this family is the anaerobic C4-dicarboxylate transporter (DcuC) of Escherichia coli. DcuC has 12 GES predicted transmembrane regions, is induced only under anaerobic conditions, and is not repressed by glucose. It may therefore function as a succinate efflux system during anaerobic glucose fermentation. However, when overexpressed, it can replace either DcuA or DcuB, which are unrelated, in catalyzing fumarate-succinate exchange and fumarate uptake.

Date:

2023-11-14

Proteins of this family usually have 11-12 transmembrane regions. They transport C4-dicarboxylates under anaerobic conditions, which plays an important role in anaerobic energy metabolism.

Gene:

dcuC

Date:

2022-10-11