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6-O-methylguanine DNA methyltransferase, ribonuclease-like domain
This entry represents the N-terminal ribonuclease-like domain associated with 6-O-methylguanine DNA methyltransferase activity. The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase (also known as O-6-methylguanine-DNA-alkyltransferase) [1]. 8156986. Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli. Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC;. EMBO J 1994;13:1495-1501. (from Pfam)
MGMT family protein
This is the C-terminal DNA-binding domain of 6-O-methylguanine-DNA methyltransferases [1]. [1]. 8156986. Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli. Moore MH, Gulbis JM, Dodson EJ, Demple B, Moody PC;. EMBO J 1994;13:1495-1501. (from Pfam)
methylated-DNA--[protein]-cysteine S-methyltransferase
methylated-DNA--[protein]-cysteine S-methyltransferase repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme, resulting in its irreversible inactivation
All proteins in this family for which functions are known are involved alkyl-DNA transferases which remove alkyl groups from DNA as part of alkylation DNA repair. Some of the proteins in this family are also transcription regulators and have a distinct transcription regulatory domain. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
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