Protein Family Models

This entry represents the N-terminal helical bundle domain from proteins in the TACO1/YebC family which are thought to act as transcriptional regulators. In mammals, The TACO1 protein activates the translation of mitochondrially-encoded COX1 [2,4]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3]. [1]. 12060744. Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus. Shin DH, Yokota H, Kim R, Kim SH;. Proc Natl Acad Sci U S A. 2002;99:7980-7985. [2]. 19503089. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmuller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA;. Nat Genet. 2009;41:833-837. [3]. 18641136. The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. Liang H, Li L, Dong Z, Surette MG, Duan K;. J Bacteriol. 2008;190:6217-6227. [4]. 27319982. Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Richman TR, Spahr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A;. Nat Commun. 2016;7:11884. (from Pfam)

Date:

2024-10-16

This is a family of transcriptional regulators. In mammals, it activates the transcription of mitochondrially-encoded COX1 [2]. In bacteria, it negatively regulates the quorum-sensing response regulator by binding to its promoter region [3]. This entry represents the second and third domains in this protein, with one domain nested within the other. [1]. 12060744. Crystal structure of conserved hypothetical protein Aq1575 from Aquifex aeolicus. Shin DH, Yokota H, Kim R, Kim SH;. Proc Natl Acad Sci U S A. 2002;99:7980-7985. [2]. 19503089. Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome. Weraarpachai W, Antonicka H, Sasarman F, Seeger J, Schrank B, Kolesar JE, Lochmuller H, Chevrette M, Kaufman BA, Horvath R, Shoubridge EA;. Nat Genet. 2009;41:833-837. [3]. 18641136. The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. Liang H, Li L, Dong Z, Surette MG, Duan K;. J Bacteriol. 2008;190:6217-6227. (from Pfam)

Date:

2024-10-16

YebC/PmpR family DNA-binding transcriptional regulator

Date:

2022-09-05

Date:

2020-10-26

Date:

2020-10-26

This model describes a minimally characterized protein family, restricted to bacteria excepting for some eukaryotic sequences that have possible transit peptides. YebC from E. coli is crystallized, and PA0964 from Pseudomonas aeruginosa has been shown to be a sequence-specific DNA-binding regulatory protein. In silico analysis suggests a role in Holliday junction resolution.

Date:

2021-05-12