Protein Family Models

This family of enzymes deaminates glutamine to glutamate EC:3.5.1.2. (from Pfam)

Date:

2024-08-14

This family describes the enzyme glutaminase, from a larger family that includes serine-dependent beta-lactamases and penicillin-binding proteins. Many bacteria have two isozymes. This model is based on selected known glutaminases and their homologs within prokaryotes, with the exclusion of highly-derived (long branch) and architecturally varied homologs, so as to achieve conservative assignments. A sharp drop in scores occurs below 250, and cutoffs are set accordingly. The enzyme converts glutamine to glutamate, with the release of ammonia. Members tend to be described as glutaminase A (glsA), where B (glsB) is unknown and may not be homologous (as in Rhizobium etli). Some species have two isozymes that may both be designated A (GlsA1 and GlsA2).

Gene:

glsA

Date:

2021-04-27

glutaminase catalyzes the conversion from L-glutamine to L-glutamate

Date:

2023-02-27

Catalyzes the formation of glutamate from glutamine

Gene:

glsA

Date:

2021-10-01