U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from Protein

Items: 8

1.

SeqA protein N-terminal domain

The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [3]. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner [3]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [4]. This short domain mediates dimerisation [5]. [1]. 9736699. High-affinity binding of hemimethylated oriC by Escherichia coli membranes is mediated by a multiprotein system that includes SeqA and a newly identified factor, SeqB. Shakibai N, Ishidate K, Reshetnyak E, Gunji S, Kohiyama M, Rothfield L;. Proc Natl Acad Sci U S A 1998;95:11117-11121. [2]. 7553853. E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration. Slater S, Wold S, Lu M, Boye E, Skarstad K, Kleckner N;. Cell 1995;82:927-936. [3]. 11457824. SeqA protein aggregation is necessary for SeqA function. Lee H, Kang S, Bae SH, Choi BS, Hwang DS;. J Biol Chem 2001;276:34600-34606. [4]. 11442835. SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor. Slominska M, Wegrzyn A, Konopa G, Skarstad K, Wegrzyn G;. Mol Microbiol 2001;40:1371-1379. [5]. 19304745. Structural insights into the cooperative binding of SeqA to a tandem GATC repeat. Chung YS, Brendler T, Austin S, Guarne A;. Nucleic Acids Res. 2009;37:3143-3152. (from Pfam)

Date:
2024-10-16
Family Accession:
NF028515.5
Method:
HMM
2.

SeqA protein C-terminal domain

The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation [3]. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner [3]. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [4]. [1]. 9736699. High-affinity binding of hemimethylated oriC by Escherichia coli membranes is mediated by a multiprotein system that includes SeqA and a newly identified factor, SeqB. Shakibai N, Ishidate K, Reshetnyak E, Gunji S, Kohiyama M, Rothfield L;. Proc Natl Acad Sci U S A 1998;95:11117-11121. [2]. 7553853. E. coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration. Slater S, Wold S, Lu M, Boye E, Skarstad K, Kleckner N;. Cell 1995;82:927-936. [3]. 11457824. SeqA protein aggregation is necessary for SeqA function. Lee H, Kang S, Bae SH, Choi BS, Hwang DS;. J Biol Chem 2001;276:34600-34606. [4]. 11442835. SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor. Slominska M, Wegrzyn A, Konopa G, Skarstad K, Wegrzyn G;. Mol Microbiol 2001;40:1371-1379. (from Pfam)

GO Terms:
Molecular Function:
DNA binding (GO:0003677)
Date:
2024-10-16
Family Accession:
NF015860.5
Method:
HMM
3.
new record, indexing in progress
Family Accession:
4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.

replication initiation negative regulator SeqA

replication initiation negative regulator SeqA binds clusters of transiently hemimethylated GATC sequences produced during DNA replication, helping to establish synchronized intiation

Date:
2018-08-21
Family Accession:
10013752
Method:
Sparcle
8.

replication initiation negative regulator SeqA

Negative modulator of the initiation of chromosome replication

Gene:
seqA
GO Terms:
Molecular Function:
DNA binding (GO:0003677)
Biological Process:
negative regulation of DNA-templated DNA replication initiation (GO:0032297)
Date:
2021-10-01
Family Accession:
NF008389.0
Method:
HMM
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center