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MucB/RseB C-terminal domain-containing protein
Members of this family are regulators of the anti-sigma E protein RseD. [1]. 8412698. Differentiation of Pseudomonas aeruginosa into the. alginate-producing form: inactivation of mucB causes conversion. to mucoidy.. Martin DW, Schurr MJ, Mudd MH, Deretic V;. Mol Microbiol 1993;9:497-506.. [2]. 8606151. Characterization of the genes coding for the putative sigma. factor AlgU and its regulators MucA, MucB, MucC, and MucD in. Azotobacter vinelandii and evaluation of their roles in alginate. biosynthesis.. Martinez-Salazar JM, Moreno S, Najera R, Boucher JC, Espin G,. Soberon-Chavez G, Deretic V;. J Bacteriol 1996;178:1800-1808.. [3]. 17496148. Crystal structure of RseB and a model of its binding mode to. RseA.. Kim DY, Jin KS, Kwon E, Ree M, Kim KK;. Proc Natl Acad Sci U S A. 2007;104:8779-8784. (from Pfam)
sigma-E factor regulatory protein RseB domain-containing protein
sigma-E factor regulatory protein RseB
sigma-E factor regulatory protein RseB interacts with the RseA and stimulates RseA binding to sigmaE
Interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
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