Protein Family Models

This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2]. [1]. 9739092. How a protein prepares for B12 binding: structure and dynamics of the B12-binding subunit of glutamate mutase from Clostridium tetanomorphum. Tollinger M, Konrat R, Hilbert BH, Marsh EN, Krautler B;. Structure 1998;6:1021-1033. [2]. 11914353. Role for vitamin B(12) in light induction of gene expression in the bacterium Myxococcus xanthus. Cervantes M, Murillo FJ;. J Bacteriol. 2002;184:2215-2224. [3]. 18315685. Vitamin B12 partners the CarH repressor to downregulate a photoinducible promoter in Myxococcus xanthus. Perez-Marin MC, Padmanabhan S, Polanco MC, Murillo FJ, Elias-Arnanz M;. Mol Microbiol. 2008;67:804-819. (from Pfam)

Date:

2024-10-16

This HMM represents the S (sigma) subunit of methylaspartate mutase (glutamate mutase), a cobalamin-dependent enzyme that catalyzes the first step in a pathway of glutamate fermentation.

Gene:

mamA

Date:

2024-06-24

methylaspartate mutase subunit S is part of the enzyme complex that catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate)

Date:

2021-02-04

Methylaspartate mutase (also called glutamate mutase) is a cob(II)alamin-dependent enzyme that interconverts methylaspartate and L-glutamate. GlmS is the sigma subunit.

Gene:

glmS

Date:

2022-03-04